RT Journal Article
SR Electronic
T1 Clinical Features and Outcomes of Takayasu Arteritis with Neurological Symptoms in China: A Retrospective Study
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1846
OP 1852
DO 10.3899/jrheum.150097
VO 42
IS 10
A1 Lirui Yang
A1 Huimin Zhang
A1 Xiongjing Jiang
A1 Lei Song
A1 Fang Qin
A1 Yubao Zou
A1 Haiying Wu
A1 Jin Bian
A1 Xianliang Zhou
A1 Rutai Hui
A1 Deyu Zheng
YR 2015
UL http://www.jrheum.org/content/42/10/1846.abstract
AB Objective. To describe the clinical features and longterm outcomes of patients with Takayasu arteritis (TA) in China who experienced neurological symptoms.Methods. A retrospective study was undertaken of patients with TA who attended a single study center from 2002 to 2013, who also exhibited neurological symptoms (n = 274). Clinical and imaging features were analyzed, as well as longterm outcomes.Results. The mean age at disease onset was 28.2 ± 11.2 years, with a female-to-male ratio of 4.3:1. The most common neurological manifestation was dizziness (214, 78.1%), the most frequent type of TA was type III (112, 40.9%), and the most common affected artery was the left subclavian (147, 53.6%). Involvement of 3 or 4 branches of the aortic arch was observed in 28% of patients. Among 30 patients experiencing a stroke (10.9%), steno-occlusive lesions of the subclavian artery and common carotid artery were frequently observed in patients with ischemic stroke, while steno-occlusive lesions of the descending aorta, abdominal aorta, and/or renal arteries were more frequently observed with hemorrhagic stroke. Heart failure was the most common cardiovascular event in those who died (n = 6) and in surviving cohorts.Conclusion. Neurological features in patients with TA were variable, and correlated with the number of arteries and the site of artery involvement. Resistant hypertension was one of the most important risk factors for hemorrhagic stroke in patients with TA.