TY - JOUR T1 - Minocycline-induced Cartilage Hyperpigmentation Mimicking Alkaptonuria in a Patient with Knee Pain JF - The Journal of Rheumatology JO - J Rheumatol SP - 825 LP - 825 DO - 10.3899/jrheum.151298 VL - 43 IS - 4 AU - JENNIFER R. STICHMAN AU - STERLING G. WEST Y1 - 2016/04/01 UR - http://www.jrheum.org/content/43/4/825.abstract N2 - Ochronosis is the bluish-black discoloration of tissues typically due to the rare autosomal-recessive metabolic disorder alkaptonuria, caused by a mutation of the HGD gene on chromosome 3. This gene mutation results in a deficiency of homogentisate 1,2-dioxygenase, leading to the accumulation and deposition of homogentisic acid in cartilage and other connective tissues. … ER -