RT Journal Article
SR Electronic
T1 High Kellgren-Lawrence Grade and Bone Marrow Lesions Predict Worsening Rates of Radiographic Joint Space Narrowing; The SEKOIA Study
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 657
OP 665
DO 10.3899/jrheum.150053
VO 43
IS 3
A1 Mark H. Edwards
A1 Camille Parsons
A1 Olivier Bruyère
A1 Forence Petit Dop
A1 Roland Chapurlat
A1 Frank W. Roemer
A1 Ali Guermazi
A1 Souhil Zaim
A1 Harry Genant
A1 Jean-Yves Reginster
A1 Elaine M. Dennison
A1 Cyrus Cooper
A1 The SEKOIA Study Group
YR 2016
UL http://www.jrheum.org/content/43/3/657.abstract
AB Objective. Determinants of radiographic progression in osteoarthritis (OA) are poorly understood. We investigated which features on baseline magnetic resonance imaging (MRI) acted as predictors of change in joint space width (JSW).Methods. A total of 559 men and women over the age of 50 years with clinical knee OA [Kellgren-Lawrence (KL) grade 2–3] were recruited to the placebo arm of the SEKOIA study (98 centers; 18 countries). Minimal tibiofemoral joint space and KL grade on plain radiograph of the knee were assessed at baseline and at yearly followup up to 3 years. In a subset, serial knee MRI examinations were performed. Individuals with a bone marrow lesion (BML) ≥ grade 2 at the tibiofemoral joint at baseline were classified as BML-positive. Relationships between change in JSW and risk factors were assessed using linear regression.Results. The mean age of study participants was 62.8 (SD 7.5) years and 73% were female; 38.6% had BML. Mean baseline JSW was 3.65 mm. This reduced by 0.18 (0.30) mm/year in men and 0.13 (0.23) mm/year in women. Those with BML had a significantly higher rate of annualized change in JSW; this relationship remained robust after adjustment for age, sex, and baseline KL grade [β = −0.10 (95% CI −0.18, −0.02) mm/yr]. Age, sex, baseline KL grade, and other MRI findings did not influence the rate of change in JSW.Conclusion. The rate of change in JSW was similar in men and women. BML on knee MRI predicted the rate of radiographic change in JSW. This relationship was independent of age, sex, and baseline KL grade.