TY - JOUR T1 - 14-3-3η in “Seronegative” Rheumatoid Arthritis JF - The Journal of Rheumatology JO - J Rheumatol SP - 1995 LP - 1995 DO - 10.3899/jrheum.150330 VL - 42 IS - 10 AU - STANLEY J. NAIDES AU - ANTHONY MAROTTA Y1 - 2015/10/01 UR - http://www.jrheum.org/content/42/10/1995.2.abstract N2 - To the Editor:Serum 14-3-3η is a novel joint-derived proinflammatory mediator implicated in the pathogenesis of rheumatoid arthritis (RA)1. Unlike rheumatoid factor (RF) or anticitrullinated protein antibody (ACPA), which can arise as a consequence of disease in sites distinct from inflamed joints, 14-3-3η hyperexpression in RA is restricted to synovial joints with a significantly higher expression in synovial fluid than matched serum2. In our recent report by Maksymowych, et al … Address correspondence to Dr. S.J. Naides, Immunology 101A, Quest Diagnostics Nichols Institute, 33608 Ortega Highway, San Juan Capistrano, California 92629, USA. E-mail: stanley.j.naides{at}questdiagnostics.com ER -