TY - JOUR T1 - Interleukin-34: A Potential Diagnostic and Therapeutic Target for Rheumatoid Arthritis JF - The Journal of Rheumatology JO - J Rheumatol SP - 553 LP - 553 DO - 10.3899/jrheum.141135 VL - 42 IS - 3 AU - WEI HE AU - XIAO-DI XU AU - YI-MAN DONG AU - HUA WU Y1 - 2015/03/01 UR - http://www.jrheum.org/content/42/3/553.1.abstract N2 - To the Editor:Recently, we read with great interest the article titled “Increased Levels of Interleukin 34 in Serum and Synovial Fluid Are Associated with Rheumatoid Factor and Anticyclic Citrullinated Peptide Antibody Titers in Patients with Rheumatoid Arthritis,” published in The Journal of Rheumatology1, showing that serum levels of interleukin 34 (IL-34) were positively correlated with rheumatoid factor (RF) and anticyclic citrullinated peptide antibody (anti-CCP) titers, but not with systemic osteoporosis and radiographic joint damage in rheumatoid arthritis (RA). Further, IL-34 levels were significantly increased in the serum of patients with RA (p < 0.001) or ankylosing spondylitis (p < 0.001) compared with controls2. These studies … Address correspondence to Dr. H. Wu, Department of Pharmacy, Binhu Hospital of Hefei City, The Third Affiliated Hospital of Anhui Medical University, 230001, Hefei, Anhui Province, China. E-mail: wuhuaedu{at}163.com ER -