RT Journal Article SR Electronic T1 Clinical Manifestations and Longterm Outcome for Patients with Takayasu Arteritis in China JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 2439 OP 2446 DO 10.3899/jrheum.140664 VO 41 IS 12 A1 Lirui Yang A1 Huimin Zhang A1 Xiongjing Jiang A1 Yubao Zou A1 Fang Qin A1 Lei Song A1 Ting Guan A1 Haiying Wu A1 Lianjun Xu A1 Yaxin Liu A1 Xianliang Zhou A1 Jin Bian A1 Rutai Hui A1 Deyu Zheng YR 2014 UL http://www.jrheum.org/content/41/12/2439.abstract AB Objective. To describe a large cohort of patients with Takayasu arteritis in China. Methods. We retrospectively analyzed 566 patients hospitalized in Fuwai Hospital between 2002 and 2013. Data collected were clinical characteristics, laboratory findings, angiographic features, treatment, and longterm outcome. Results. The female to male ratio was 3.8 to 1, and the mean age of onset was 28.9 ± 12.0 years. The most common inflammatory symptom, initial symptom, and coexisting disease were fever (52, 9.2%), dizziness (214, 37.8%), and hypertension (HTN; 392, 69.3%), respectively. Pulmonary artery, coronary artery involvement, and aortic regurgitation were found in 83 (14.7%), 66 (11.7%), and 181 (36.7%) patients, respectively. Elevation of the erythrocyte sedimentation rate was observed in 131 patients (23.1%). Treatment included drugs, interventional therapy, autologous blood vessel transplant, artificial blood vessel transplant, and aortic valve replacement. During a mean followup of 5.0 ± 0.2 years, 32 patients died, including 1 patient who died suddenly during coronary angiography. HTN, major complications, and a progressive disease course were significant prognostic markers. Conclusion. HTN, rather than fever, is the leading reason for patients with Takayasu arteritis to see a doctor in China. HTN, major complications, and a progressive disease course are statistically significant predictors of survival. Because of cardiovascular events associated with the disease, early diagnosis and treatment are urgent to improve prognosis.