RT Journal Article SR Electronic T1 Development and Preliminary Validation of the Spondyloarthritis Research Consortium of Canada Magnetic Resonance Imaging Sacroiliac Joint Structural Score JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 79 OP 86 DO 10.3899/jrheum.140519 VO 42 IS 1 A1 Walter P. Maksymowych A1 Stephanie Wichuk A1 Praveena Chiowchanwisawakit A1 Robert G. Lambert A1 Susanne J. Pedersen YR 2015 UL http://www.jrheum.org/content/42/1/79.abstract AB Objective. There is an unmet need for reliable assessment of structural progression in the sacroiliac joints (SIJ) of patients with spondyloarthritis (SpA), but radiography is unreliable and lacks responsiveness. We aimed to develop and validate a new scoring method for structural lesions based on magnetic resonance imaging (MRI), the Spondyloarthritis Research Consortium of Canada (SPARCC) SIJ Structural Score (SSS). Methods. The SSS method for assessment of structural lesions is based on T1-weighted spin echo MRI, validated lesion definitions, slice selection according to well-defined anatomical principles, and dichotomous scoring (lesion present/absent) of 5 consecutive slices through the cartilaginous portion of the joint. Scoring ranges are fat metaplasia (0–40), erosion (0–40), backfill (0–20), and ankylosis (0–20). We progressively conducted 3 validation exercises with 2–4 readers on baseline, and either 2-year (exercises 1 and 2) or 1-year (exercise 3) scans from 147 patients with SpA assessed blinded to timepoint. Interobserver reliability was assessed by intraclass correlation coefficient (ICC) and smallest detectable change (SDC). Results. Interobserver reliability for status score was good to excellent for ankylosis (ICC 0.79–0.98), consistently good for fat metaplasia (ICC 0.71–0.78), moderate to good for erosion (ICC 0.58–0.62), and fair to good for backfill (ICC 0.35–0.66). Reliability for change scores was moderate to good for all structural lesions despite the relatively small changes in scores, and was highest for fat metaplasia when both ICC and SDC values were compared. Conclusion. The new SPARCC MRI SSS method can detect structural changes in the SIJ with acceptable reliability over a 1–2-year timeframe, and should be further validated in patients with SpA.