TY - JOUR T1 - Alpha-Chlorofatty Acid and Coronary Artery or Aorta Calcium Scores in Women with Systemic Lupus Erythematosus. A Pilot Study JF - The Journal of Rheumatology JO - J Rheumatol SP - 1834 LP - 1842 DO - 10.3899/jrheum.131361 VL - 41 IS - 9 AU - Mary A. Mahieu AU - Camelia P. Guild AU - Carolyn J. Albert AU - George T. Kondos AU - James J. Carr AU - Daniel Edmundowicz AU - David A. Ford AU - Rosalind Ramsey-Goldman Y1 - 2014/09/01 UR - http://www.jrheum.org/content/41/9/1834.abstract N2 - Objective. Alpha-chlorofatty acid (α-ClFA) is one product of myeloperoxidase activity in vivo during atherogenesis and may be a biomarker for cardiovascular disease (CVD). We investigated if serum α-ClFA is associated with subclinical CVD as measured by coronary artery and aorta calcium scores (CAC and AC, respectively) in women with and without systemic lupus erythematosus (SLE). Methods. This pilot project analyzed baseline data from 173 women with SLE and 186 women without SLE participating in a 5-year longitudinal investigation of the Study of Lupus Vascular and Bone Long-term Endpoints (SOLVABLE). Data collection included demographic information, CVD and SLE risk factors, and laboratory assessments. Alpha-ClFA was measured in stored serum by liquid chromatography-mass spectrometry. CAC and AC were measured by computed tomography. Outcome measures were CAC and AC present (CAC > 0 or AC > 0) versus absent (CAC = 0 or AC = 0). Associations between risk factors and CAC or AC were tested with descriptive statistics and multivariate analyses. Results. Women with SLE had higher α-ClFA levels than women without SLE (42.0 fmol/25 µl ± 37.3 vs 34.5 fmol/25 µl ± 21.9; p = 0.020). In analyses including individual CVD risk factors, having SLE was independently associated with the presence of CAC (OR 3.42, 95% CI 1.72 to 6.78) but not AC. Alpha-ClFA was not associated with the presence of CAC or AC in patients with SLE. Conclusion. SLE, but not serum α-ClFA, was associated with the presence of CAC in this pilot project. ER -