@article {Mouterde1614, author = {Ga{\"e}l Mouterde and C{\'e}dric Lukas and Philippe Goupille and Ren{\'e}-Marc Flipo and Nathalie Rincheval and Jean-Pierre Daur{\`e}s and Bernard Combe}, title = {Association of Anticyclic Citrullinated Peptide Antibodies and/or Rheumatoid Factor Status and Clinical Presentation in Early Arthritis: Results from the ESPOIR Cohort}, volume = {41}, number = {8}, pages = {1614--1622}, year = {2014}, doi = {10.3899/jrheum.130884}, publisher = {The Journal of Rheumatology}, abstract = {Objective. To compare the initial clinical, biological, and radiographic findings of early arthritis by positivity for rheumatoid factor (RF) and/or anticyclic citrullinated peptide antibodies (anti-CCP), and to validate a patient profile based on this serologic information. Methods. The ESPOIR cohort comprises patients presenting synovitis of at least 2 joints for 6 weeks to 6 months. Patients underwent testing for IgM rheumatoid factor (IgM-RF) and anti-CCP2 antibodies and were divided into 4 groups: RF{\textendash} and anti-CCP{\textendash} (group 1), RF+ and anti-CCP{\textendash} (group 2), RF{\textendash} and anti-CCP+ (group 3), RF+ and anti-CCP+ (group 4). We compared the groups in terms of clinical, biological, and radiographic features (baseline scores and 6-month and 12-month progression). Results. Of the 813 recruited patients, 406 (50\%) were in group 1, 91 (11.2\%) in group 2, 34 (4.1\%) in group 3, and 281 (34.6\%) in group 4. Mean baseline erythrocyte sedimentation rate and C-reactive protein were higher for anti-CCP+ groups (groups 3 and 4) than for other groups (p \< 0.001), and van der Heijde-modified Sharp score for radiographs was higher for group 4 than for other groups (p \< 0.001). Clinical presentation was not consistently associated with serologic profile. Radiographic progression at 1 year was higher for anti-CCP+ groups than other groups (p \< 0.001). Conclusion. The phenotype of patients with early arthritis with or without anti-CCP and/or RF positivity did not correspond to a particular clinical presentation. However, baseline acute-phase reactants and short-term radiographic progression were high in patients with anti-CCP positivity, which may be associated with the inflammatory process and progressive disease in patients with early arthritis.}, issn = {0315-162X}, URL = {https://www.jrheum.org/content/41/8/1614}, eprint = {https://www.jrheum.org/content/41/8/1614.full.pdf}, journal = {The Journal of Rheumatology} }