RT Journal Article
SR Electronic
T1 Synovitis in Knee Osteoarthritis Assessed by Contrast-enhanced Magnetic Resonance Imaging (MRI) is Associated with Radiographic Tibiofemoral Osteoarthritis and MRI-detected Widespread Cartilage Damage: The MOST Study
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 501
OP 508
DO 10.3899/jrheum.130541
VO 41
IS 3
A1 Ali Guermazi
A1 Daichi Hayashi
A1 Frank W. Roemer
A1 Yanyan Zhu
A1 Jingbo Niu
A1 Michel D. Crema
A1 M. Kassim Javaid
A1 Monica D. Marra
A1 John A. Lynch
A1 George Y. El-Khoury
A1 Yuqing Zhang
A1 Michael C. Nevitt
A1 David T. Felson
YR 2014
UL http://www.jrheum.org/content/41/3/501.abstract
AB Objective. To examine the cross-sectional association of whole-knee synovitis assessed by contrast-enhanced magnetic resonance imaging (CEMRI) with radiographic tibiofemoral osteoarthritis (OA), non-CEMRI-assessed cartilage damage, and meniscal status. Methods. Multicenter Osteoarthritis Study (MOST) is a cohort study of people with or at high risk of knee OA. Subjects are a subset of MOST who volunteered for both CEMRI and non-CEMRI. Using CEMRI, synovitis was assessed at 11 sites and graded 0–2 at each site. Presence of “whole-knee synovitis” was defined as the synovitis score of ≥ 1 at any site from each knee. Cartilage and meniscal damage was evaluated using non-CEMRI based on the Whole Organ MRI Score. Logistic regression was used to assess associations of synovitis with radiographic OA (Kellgren-Lawrence grade ≥ 2), widespread cartilage damage, and meniscal damage, adjusting for age, sex, and body mass index (BMI). Additional analyses were performed excluding subjects who had chondrocalcinosis on radiography and those taking antiinflammatory medications. Results. Four hundred four subjects were included (mean age 58.8 ± 7.0 yrs, BMI 29.6 ± 4.9 kg/m2, 45.5% women). On CEMRI, the maximum synovitis score across 11 sites in each knee was 0 in 106 knees (26.2%), 1 in 135 (33.4%), and 2 in 163 (40.4%). Synovitis was associated with radiographic OA [adjusted OR (aOR) 3.25, 95% CI 1.98–5.35] and widespread cartilage damage (aOR 1.91, 95% CI 1.24–2.92). Severe meniscal damage showed a borderline significant association with synovitis (aOR 1.74, 95% CI 0.99–3.04). Additional analyses as described did not notably change the results. Conclusion. CEMRI-detected synovitis is strongly associated with tibiofemoral radiographic OA and MRI-detected widespread cartilage damage.