RT Journal Article
SR Electronic
T1 Influence of Psychological Stress on Headache in Patients with Systemic Lupus Erythematosus
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 453
OP 457
DO 10.3899/jrheum.130535
VO 41
IS 3
A1 José Antonio Vargas-Hitos
A1 José Mario Sabio
A1 Isabel Martínez-Egea
A1 Enrique Jiménez-Jáimez
A1 Manuel Rodríguez-Guzmán
A1 Nuria Navarrete-Navarrete
A1 Esther López-Lozano
A1 Ángela Romero-Alegría
A1 Cristina de la Calle
A1 Laura Jáimez-Gámiz
A1 Pilar Baños-Piñero
A1 Fernando Nebrera-Navarro
A1 Alba Fidalgo
A1 Luis Caminal
A1 Enrique de Ramón Garrido
A1 Norberto Ortego-Centeno
A1 Manuela Expósito
A1 Mónica Zamora-Pasadas
A1 Juan Jiménez-Alonso
YR 2014
UL http://www.jrheum.org/content/41/3/453.abstract
AB Objective. To compare the prevalence and disability of headache in patients with systemic lupus erythematosus (SLE) with the general population and to assess the role of chronic psychological stress (CPS) in headache development. Methods. One hundred seventy patients with SLE and 102 control subjects matched for age, sex, and level of education were included in this multicenter, cross-sectional study. CPS, headache-related disability, and chronic analgesic intake (CAI) were evaluated in all participants. Results. No statistical differences in the prevalence of headache between both groups were observed but headache disability was significantly higher in patients with SLE. In addition, a higher average score in the Cohen Perceived Stress Scale (CPSS) and a higher prevalence of patients with CAI were observed in patients with SLE. In multivariate analysis, CPSS score was positively (OR 1.09; 95% CI: 1.03–1.14; p = 0.001) and CAI negatively (OR 0.43; 95% CI: 0.19–0.99; p = 0.049) associated with headache in patients with SLE. Conclusion. Despite the prevalence of headache in patients with SLE and the general population being similar, headache-related disability may be higher in patients with SLE. Moreover, CPS might play a role in the pathogenesis of SLE headache, whereas CAI might have a protective effect against it.