@article {Vargas-Hitos453, author = {Jos{\'e} Antonio Vargas-Hitos and Jos{\'e} Mario Sabio and Isabel Mart{\'\i}nez-Egea and Enrique Jim{\'e}nez-J{\'a}imez and Manuel Rodr{\'\i}guez-Guzm{\'a}n and Nuria Navarrete-Navarrete and Esther L{\'o}pez-Lozano and {\'A}ngela Romero-Alegr{\'\i}a and Cristina de la Calle and Laura J{\'a}imez-G{\'a}miz and Pilar Ba{\~n}os-Pi{\~n}ero and Fernando Nebrera-Navarro and Alba Fidalgo and Luis Caminal and Enrique de Ram{\'o}n Garrido and Norberto Ortego-Centeno and Manuela Exp{\'o}sito and M{\'o}nica Zamora-Pasadas and Juan Jim{\'e}nez-Alonso}, title = {Influence of Psychological Stress on Headache in Patients with Systemic Lupus Erythematosus}, volume = {41}, number = {3}, pages = {453--457}, year = {2014}, doi = {10.3899/jrheum.130535}, publisher = {The Journal of Rheumatology}, abstract = {Objective. To compare the prevalence and disability of headache in patients with systemic lupus erythematosus (SLE) with the general population and to assess the role of chronic psychological stress (CPS) in headache development. Methods. One hundred seventy patients with SLE and 102 control subjects matched for age, sex, and level of education were included in this multicenter, cross-sectional study. CPS, headache-related disability, and chronic analgesic intake (CAI) were evaluated in all participants. Results. No statistical differences in the prevalence of headache between both groups were observed but headache disability was significantly higher in patients with SLE. In addition, a higher average score in the Cohen Perceived Stress Scale (CPSS) and a higher prevalence of patients with CAI were observed in patients with SLE. In multivariate analysis, CPSS score was positively (OR 1.09; 95\% CI: 1.03{\textendash}1.14; p = 0.001) and CAI negatively (OR 0.43; 95\% CI: 0.19{\textendash}0.99; p = 0.049) associated with headache in patients with SLE. Conclusion. Despite the prevalence of headache in patients with SLE and the general population being similar, headache-related disability may be higher in patients with SLE. Moreover, CPS might play a role in the pathogenesis of SLE headache, whereas CAI might have a protective effect against it.}, issn = {0315-162X}, URL = {https://www.jrheum.org/content/41/3/453}, eprint = {https://www.jrheum.org/content/41/3/453.full.pdf}, journal = {The Journal of Rheumatology} }