TY - JOUR T1 - Common Variants of <em>cGKII/PRKG2</em> Are Not Associated with Gout Susceptibility JF - The Journal of Rheumatology JO - J Rheumatol SP - 1395 LP - 1397 DO - 10.3899/jrheum.131548 VL - 41 IS - 7 AU - Masayuki Sakiyama AU - Hirotaka Matsuo AU - Toshinori Chiba AU - Akiyoshi Nakayama AU - Takahiro Nakamura AU - Seiko Shimizu AU - Emi Morita AU - Nana Fukuda AU - Hiroshi Nakashima AU - Yutaka Sakurai AU - Kimiyoshi Ichida AU - Toru Shimizu AU - Nariyoshi Shinomiya Y1 - 2014/07/01 UR - http://www.jrheum.org/content/41/7/1395.abstract N2 - Objective. Recently, genetic analyses indicated the association between gout and cGMP-dependent protein kinase 2 (cGKII/PRKG2) gene in a Fukien-Taiwanese heritage population. However, no replication study has been reported in other ancestries. Therefore, we investigated this association in a Japanese population. Methods. Genotyping of 4 variants (rs11736177, rs10033237, rs7688672, and rs6837293) of cGKII was performed in 741 male gout patients and 1302 male controls. Results. cGKII variants have no association with gout. Conclusion. Our replication study suggests that cGKII is not involved in gout susceptibility. ER -