PT  - JOURNAL ARTICLE
AU  - Inge R. Klein-Wieringa
AU  - Stefan N. Andersen
AU  - Linda Herb-van Toorn
AU  - Joanneke C. Kwekkeboom
AU  - Anette H.M. van der Helm-van Mil
AU  - Ingrid Meulenbelt
AU  - Tom W.J. Huizinga
AU  - Margreet Kloppenburg
AU  - René E.M. Toes
AU  - Andreea Ioan-Facsinay
TI  - Are Baseline High Molecular Weight Adiponectin Levels Associated with Radiographic Progression in Rheumatoid Arthritis and Osteoarthritis?
AID  - 10.3899/jrheum.130888
DP  - 2014 May 01
TA  - The Journal of Rheumatology
PG  - 853--857
VI  - 41
IP  - 5
4099  - http://www.jrheum.org/content/41/5/853.short
4100  - http://www.jrheum.org/content/41/5/853.full
SO  - J Rheumatol2014 May 01; 41
AB  - Objective. To investigate whether high molecular weight adiponectin (hmwAPN) mediates the associations of total adiponectin (totAPN) with radiographic progression in rheumatoid arthritis (RA) and hand osteoarthritis (HOA). Methods. Associations between baseline hmwAPN or totAPN levels with radiographic progression were determined using multivariate linear regression or generalized estimated equations. Results. In patients with RA, totAPN associated positively, whereas in patients with HOA it associated negatively with radiographic progression. In contrast, hmwAPN did not associate significantly with radiographic progression in either cohort. Conclusion. Our data indicate that the differential effects associated between totAPN and radiographic progression in either RA or HOA are not mediated by hmwAPN.