RT Journal Article
SR Electronic
T1 Effect of Enthesitis on 1505 Brazilian Patients with Spondyloarthritis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1719
OP 1725
DO 10.3899/jrheum.121145
VO 40
IS 10
A1 Sueli Carneiro
A1 Adriana Bortoluzzo
A1 Celio Gonçalves
A1 José Antonio Braga da Silva
A1 Antonio C. Ximenes
A1 Manoel Bértolo
A1 Sandra Lúcia Ribeiro
A1 Mauro Keiserman
A1 Thelma Skare
A1 Rita Menin
A1 Valderilio Azevedo
A1 Walber Vieira
A1 Elisa Albuquerque
A1 Washington Bianchi
A1 Rubens Bonfiglioli
A1 Cristiano Campanholo
A1 Hellen Mary de Carvalho
A1 Izaias da Costa
A1 Ángela Duarte
A1 Charles Kohem
A1 Nocy Leite
A1 Sonia A.L. Lima
A1 Eduardo S. Meirelles
A1 Ivânio A. Pereira
A1 Marcelo M. Pinheiro
A1 Elizandra Polito
A1 Gustavo G. Resende
A1 Francisco Airton C. Rocha
A1 Mittermayer B. Santiago
A1 Maria de Fátima L.C. Sauma
A1 Valéria Valim
A1 Percival D. Sampaio-Barros
YR 2013
UL http://www.jrheum.org/content/40/10/1719.abstract
AB Objective. To analyze the clinical effect of enthesitis in a large Brazilian cohort of patients with spondyloarthritis (SpA). Methods. A common protocol of investigation was prospectively applied to 1505 patients with SpA in 29 centers in Brazil. Clinical and demographic variables and disease indexes were investigated. The Maastricht Ankylosing Spondylitis Enthesitis Score was used to investigate the enthesitis component. Ankylosing spondylitis was the most frequent disease in the group (65.4%). Others were psoriatic arthritis (18.4%), undifferentiated SpA (6.7%), reactive arthritis (3.3%), and enteropathic arthritis (3.2%). Results. At least 1 affected enthesis was observed in 54% of the patients with SpA, with a mean of 2.12 ± 2.98 entheses affected. According to the clinical presentation, enthesitis was significantly more frequent in patients with axial + peripheral joint involvement compared to isolated axial or peripheral involvement (p < 0.001). There was a statistical association between the presence of enthesites and axial symptoms (buttock pain, cervical pain, and hip pain), and peripheral symptoms (lower limb arthritis, number of painful and swollen joints; p < 0.05). Patients with enthesitis also presented higher mean scores of Bath Ankylosing Spondylitis Functional Index (BASFI; p < 0.001), Bath Ankylosing Spondylitis Disease Activity Index (p < 0.001), and Ankylosing Spondylitis Quality of Life (ASQoL; p < 0.001). Multivariate logistic regression showed that BASFI (p < 0.0001; OR 74.839), ASQoL (p = 0.0001; OR 14.645), and Achilles tendonitis (p = 0.0059; OR 7.593) were associated with work incapacity. Conclusion. The clinical presence of enthesitis in this large cohort of patients with SpA was frequent and was associated with a significant increase in disease activity and decline in functional capacity and quality of life.