RT Journal Article
SR Electronic
T1 Outcome of Pregnancy in Italian Patients with Primary Sjögren Syndrome
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1143
OP 1147
DO 10.3899/jrheum.121518
VO 40
IS 7
A1 Roberta Priori
A1 Angelica Gattamelata
A1 Mariagrazia Modesti
A1 Serena Colafrancesco
A1 Silvia Frisenda
A1 Antonina Minniti
A1 Marialuisa Framarino-dei-Malatesta
A1 Marta Maset
A1 Luca Quartuccio
A1 Salvatore De Vita
A1 Elena Bartoloni
A1 Alessia Alunno
A1 Roberto Gerli
A1 Francesca Strigini
A1 Chiara Baldini
A1 Chiara Tani
A1 Marta Mosca
A1 Stefano Bombardieri
A1 Guido Valesini
YR 2013
UL http://www.jrheum.org/content/40/7/1143.abstract
AB Objective. To investigate pregnancy and fetal outcomes in patients with primary Sjögren syndrome (pSS). Methods. An obstetric history of 36 women with established diagnosis of pSS at pregnancy was obtained from a multicenter cohort of 1075 patients. In a subgroup case-control analysis, 12 deliveries in patients with pSS were compared with 96 control deliveries. Results. Thirty-six women (31 with anti-SSA/Ro and/or anti-SSB/La antibodies) with an established diagnosis of pSS had 45 pregnancies with the delivery of 40 newborns. Two miscarriages, 2 fetal deaths, and 1 induced abortion were recorded. Mean age at the first pregnancy was 33.9 years; mean number of pregnancies was 1.25; 18/40 (45%) cesarean births were delivered; mean pregnancy length was 38.5 weeks (range 32–43), with 6 preterm deliveries. The mean Apgar score at 5 min was 8.9, mean birthweight was 2920 g (range 826–4060 g). Congenital heart block (CHB) occurred in 2/40 (5%) newborns. The reported rate of breastfeeding for at least 1 month was 60.5%. In 4/40 pregnancies (10%) a flare of disease activity was observed within a year from delivery. In the case-control subgroup analysis, 12 deliveries were compared with 96 controls and no significant differences were found. Conclusion. Patients with pSS can have successful pregnancies, which might be followed by a mild relapse. CHB was the only cause of death for offspring of mothers with pSS.