RT Journal Article
SR Electronic
T1 Replication of European Rheumatoid Arthritis Loci in a Pakistani Population
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 401
OP 407
DO 10.3899/jrheum.121050
VO 40
IS 4
A1 Syed Fazal Jalil
A1 Attya Bhatti
A1 F. Yesim Demirci
A1 Xingbin Wang
A1 Iltaf Ahmed
A1 Mushtaq Ahmed
A1 M. Michael Barmada
A1 Javaid M. Malik
A1 Peter John
A1 M. Ilyas Kamboh
YR 2013
UL http://www.jrheum.org/content/40/4/401.abstract
AB Objective. Genetic studies have identified several rheumatoid arthritis (RA) susceptibility loci in European-derived populations. The same biological pathways may be involved in determining the RA risk in different population groups. We sought to replicate the association of 33 single-nucleotide polymorphisms (SNP) from 31 RA susceptibility loci confirmed among Europeans in a unique Pakistani population. Methods. We genotyped 33 SNP in a sample of 366 Pakistanis that comprised related and unrelated cases and controls. Genotyping was performed using TaqMan assays and the results were analyzed with family case-control software. Results. Twelve of the 33 SNP were replicated in this sample with significant p values ranging from 7.05E-06 to 3.72E-02, the most significant being the KIF5A-PIP4K2C/rs1678542 SNP. Conclusion. Our observations suggest that a number of RA susceptibility loci and related pathways are shared across different populations.