PT  - JOURNAL ARTICLE
AU  - Teng Sun
AU  - Huimin Zhang
AU  - Wenjun Ma
AU  - Lirui Yang
AU  - Xiongjing Jiang
AU  - Haiying Wu
AU  - Rutai Hui
AU  - Deyu Zheng
TI  - Coronary Artery Involvement in Takayasu Arteritis in 45 Chinese Patients
AID  - 10.3899/jrheum.120813
DP  - 2013 Apr 01
TA  - The Journal of Rheumatology
PG  - 493--497
VI  - 40
IP  - 4
4099  - http://www.jrheum.org/content/40/4/493.short
4100  - http://www.jrheum.org/content/40/4/493.full
SO  - J Rheumatol2013 Apr 01; 40
AB  - Objective. We investigated the clinical characteristics, potential difficulties in diagnosis, and therapy for coronary artery involvement in patients with Takayasu arteritis (TA). Methods. Of 587 consecutive patients hospitalized with TA from 1998 to 2011, those found to have > 50% reduction of diameter of coronary artery by angiography were recruited. We defined the first finding of coronary involvement as baseline. The clinical features, laboratory data, coronary angiographic findings, treatment, and followup outcomes were summarized retrospectively. Results. A total of 45 (7.7%, 45/587) patients with coronary involvement were identified, including 40 with typical angina, and 15 with myocardial infarction. Some had complications such as peripheral vascular murmur, pulseless disease, and hypertension. The average age at onset of cardiac symptoms was 40.3 ± 12.8 years (range 15–64) and 36 were female. At admission, erythrocyte sedimentation rates were elevated in 27 patients (60%) and C-reactive protein levels in 23 (51.1%). The ostia (37.4%) and proximal segments (33.3%) of coronary artery were most frequently involved. The treatment was stent implantation in 10 patients and coronary artery bypass grafting in 13. One female patient suffered sudden death during the angiography. During a mean followup of 5.8 ± 4.5 years, 8 patients died. Conclusion. Coronary artery involvement in TA that leads to cardiovascular events, especially to cardiovascular death, is not rare. Early diagnosis and therapy should be emphasized.