PT  - JOURNAL ARTICLE
AU  - OLIVER FITZGERALD
AU  - CHRISTOPHER T. RITCHLIN
AU  - PHILIP J. MEASE
TI  - Biomarkers of Radiographic Progression in Psoriatic Arthritis: A Report from the GRAPPA 2011 Annual Meeting
AID  - 10.3899/jrheum.120820
DP  - 2012 Nov 01
TA  - The Journal of Rheumatology
PG  - 2189--2192
VI  - 39
IP  - 11
4099  - http://www.jrheum.org/content/39/11/2189.short
4100  - http://www.jrheum.org/content/39/11/2189.full
SO  - J Rheumatol2012 Nov 01; 39
AB  - Clinical markers of radiographic progression have been studied in patients with psoriatic arthritis (PsA), and results have clearly confirmed the progression of radiographic damage over a 2-year period. Biomarkers of radiographic progression damage (erosion and new bone formation) have also been identified as a critical research issue in these patients. At the 2011 annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), members discussed development of a pivotal observational study (PsA Biodam study) to determine the validity of several soluble biomarkers in predicting structural damage in patients with PsA receiving standard therapies. Specific protocol issues discussed were the inclusion criteria, selection of candidate biomarkers, timing of sample collection, the primary radiographic outcome measure, radiographic scoring methods, possible substudies, and funding strategies.