TY - JOUR T1 - Etanercept Allergy and Anaphylaxis JF - The Journal of Rheumatology JO - J Rheumatol SP - 2225 LP - 2227 DO - 10.3899/jrheum.120791 VL - 39 IS - 11 AU - ANNE QUISMORIO AU - BHAUMIK BRAHMBHATT AU - MINDY HOUNG AU - RICHARD S. PANUSH Y1 - 2012/11/01 UR - http://www.jrheum.org/content/39/11/2225.abstract N2 - To the Editor:Etanercept has been an effective, well tolerated medication with uncommon and usually acceptable adverse effects. We are aware of only 4 reports describing possible/probable etanercept allergy/anaphylaxis1,2,3,4,5. We describe 2 patients with allergic/anaphylactoid reactions to etanercept, review the literature, and comment on pertinent management issues.A 49-year-old woman with a history of atopy and anaphylactoid/angioedematous symptoms to soy milk developed rheumatoid arthritis (RA) in 2009. She was started on prednisone, minocycline, sulfasalazine, ibuprofen, and hydroxychloroquine, with a poor response. She was then prescribed etanercept 50 mg weekly subcutaneously, which rendered her asymptomatic. However, after several months she reported increasingly frequent and severe episodes characterized by urticaria and swelling of the periorbital regions and her tongue within hours following administration of etanercept, requiring diphenhydramine, epinephrine, and corticosteroids. Etanercept was discontinued and there has been no recurrence of these events.A 27-year-old woman presented in 2005 with persistent rash, fevers, … Address correspondence to Dr. R.S. Panush, 2011 Zonal Ave., HMR 711, Keck School of Medicine, University of Southern California, Los Angeles, CA 90032, USA. E-mail: panush{at}usc.edu ER -