PT - JOURNAL ARTICLE AU - CHIKAKO KIYOHARA AU - MASAKAZU WASHIO AU - TAKAHIKO HORIUCHI AU - TOYOKO ASAMI AU - SABURO IDE AU - TATSUYA ATSUMI AU - GEN KOBASHI AU - YOSHIFUMI TADA AU - HIROKI TAKAHASHI AU - Kyushu Sapporo SLE (KYSS) Study Group TI - Cigarette Smoking, Alcohol Consumption, and Risk of Systemic Lupus Erythematosus: A Case-control Study in a Japanese Population AID - 10.3899/jrheum.111609 DP - 2012 Jul 01 TA - The Journal of Rheumatology PG - 1363--1370 VI - 39 IP - 7 4099 - http://www.jrheum.org/content/39/7/1363.short 4100 - http://www.jrheum.org/content/39/7/1363.full SO - J Rheumatol2012 Jul 01; 39 AB - Objective. Cigarette smoking may be associated with increased risk of systemic lupus erythematosus (SLE), whereas the role of alcohol consumption is unknown. We examined the association between SLE risk and smoking or drinking. Methods. We investigated the relationship of smoking and drinking compared to SLE risk among 171 SLE cases and 492 healthy controls in female Japanese subjects. Unconditional logistic regression was used to compute OR and 95% CI, with adjustments for several covariates. Results. Compared with nonsmoking, current smoking was significantly associated with increased risk of SLE (OR 3.06, 95% CI 1.86–5.03). The higher the level of exposure to cigarette smoke, the higher the risk of SLE. Inhalation was also associated with increased SLE risk (OR 3.73, 95% CI 1.46–9.94 for moderate inhalation; OR 3.06, 95% CI 1.81–5.15 for deep inhalation). In contrast, light/moderate alcohol consumption had a protective effect on SLE risk (OR 0.38, 95% CI 0.19–0.76). As for beer, the risks for non-beer drinkers and beer drinkers were similar. This also applies to alcoholic beverages other than beer. Conclusion. Our results suggest that smoking was positively associated with increased SLE risk whereas light/moderate alcohol consumption was inversely associated with SLE risk, irrespective of the type of alcoholic beverage. Additional studies are warranted to confirm these findings.