TY - JOUR T1 - Colchicine Use Is Associated with Decreased Prevalence of Myocardial Infarction in Patients with Gout JF - The Journal of Rheumatology JO - J Rheumatol SP - 1458 LP - 1464 DO - 10.3899/jrheum.111533 VL - 39 IS - 7 AU - DARIA B. CRITTENDEN AU - R. AARON LEHMANN AU - LAURA SCHNECK AU - ROBERT T. KEENAN AU - BINITA SHAH AU - JEFFREY D. GREENBERG AU - BRUCE N. CRONSTEIN AU - STEVEN P. SEDLIS AU - MICHAEL H. PILLINGER Y1 - 2012/07/01 UR - http://www.jrheum.org/content/39/7/1458.abstract N2 - Objective. The ability of antiinflammatory strategies to alter cardiovascular risk has not been rigorously examined. Colchicine is an antiinflammatory agent that affects macrophages, neutrophils, and endothelial cells, all of which are implicated in the pathogenesis of cardiovascular disease. We examined whether colchicine use was associated with a reduced risk of myocardial infarction (MI) in patients with gout. Methods. We conducted a retrospective, cross-sectional study of all patients with an International Classification of Diseases, 9th ed, code for gout in the electronic medical record (EMR) of the New York Harbor Healthcare System Veterans Affairs network and ≥ 1 hospital visit between August 2007 and August 2008. Hospital pharmacy data were used to identify patients who had filled at least 1 colchicine prescription versus those who had not. Demographics and CV comorbidities were collected by EMR review. The primary outcome was diagnosis of MI. Secondary outcomes included all-cause mortality and C-reactive protein (CRP) level. Results. In total, 1288 gout patients were identified. Colchicine (n = 576) and no colchicine (n = 712) groups had similar baseline demographics and serum urate levels. Prevalence of MI was 1.2% in the colchicine versus 2.6% in the no-colchicine group (p = 0.03). Colchicine users also had fewer deaths and lower CRP levels, although these did not achieve statistical significance. Colchicine effects persisted when allopurinol users were excluded from the analysis. Conclusion. In this hypothesis-generating study, gout patients who took colchicine had a significantly lower prevalence of MI and exhibited trends toward reduced all-cause mortality and lower CRP level versus those who did not take colchicine. ER -