TY - JOUR T1 - Hand Enthesophytes and Knee Enthesopathy: Is Osteoarthritis Related to a Systemic Enthesopathy? JF - The Journal of Rheumatology JO - J Rheumatol SP - 1481 LP - 1481 DO - 10.3899/jrheum.120332 VL - 39 IS - 7 AU - AI LYN TAN AU - DENNIS McGONAGLE Y1 - 2012/07/01 UR - http://www.jrheum.org/content/39/7/1481.1.abstract N2 - To the Editor:We read with interest the recent article by Gibson and colleagues1 and the accompanying editorial2 on the role of enthesopathy in osteoarthritis (OA). Gibson, et al suggest that OA is not a systemic enthesopathic disease, based on the finding that there is no increase in radiographically determined hand enthesophytes in subjects with bone marrow lesions of the knee1. We contend that there is insufficient evidence from the study to make such a claim.It is considered that isolated knee OA and knee bone marrow lesions are relatively more sensitive to mechanical and trauma-related stressors like obesity and injuries3,4, while hand OA has a stronger genetic basis5, a case of nurture (or lack of, in the case … Address correspondence to Dr. Tan; E-mail: a.l.tan{at}leeds.ac.uk ER -