TY - JOUR T1 - NPSR1 Gene Is Associated with Reduced Risk of Rheumatoid Arthritis JF - The Journal of Rheumatology JO - J Rheumatol SP - 1166 LP - 1170 DO - 10.3899/jrheum.111205 VL - 39 IS - 6 AU - GEMA ROBLEDO AU - MIGUEL ANGEL GONZÁLEZ-GAY AU - BENJAMÍN FERNÁNDEZ-GUTIÉRREZ AU - JOSÉ RAMÓN LAMAS AU - ALEJANDRO BALSA AU - DORA PASCUAL-SALCEDO AU - SANTOS CASTAÑEDA AU - RICARDO BLANCO AU - ISIDORO GONZÁLEZ-ALVARO AU - ANTONIO GARCÍA AU - ENRIQUE RAYA AU - CARMEN GÓMEZ-VAQUERO AU - MARIO DELGADO AU - JAVIER MARTÍN Y1 - 2012/06/01 UR - http://www.jrheum.org/content/39/6/1166.abstract N2 - Objective. Neuropeptide S receptor 1 (NPSR1) is a G protein-coupled receptor involved in immune response and is associated with several inflammatory diseases. We investigated the possible contribution of several polymorphisms in the intronic region of NPSR1 to rheumatoid arthritis (RA). Methods. Genotyping of 7 single-nucleotide polymorphisms (SNP) was performed in a total of 1232 patients with RA and 983 healthy controls of Spanish white origin by real-time polymerase chain reaction technology, using the TaqMan 5′-allele discrimination assay. Results. One out of the 7 SNP analyzed (rs740347) was associated with RA [p after Bonferroni correction (pBNF) = 1.2 × 10−3, OR 0.73]. An association was also observed with rheumatoid factor-positive and shared epitope-positive RA (pBNF = 0.011, OR 0.73; pBNF = 0.037, OR 0.75, respectively). Conclusion. Our results show that variations in the NPSR1 intronic region are associated with low risk in patients with RA, supporting other evidence that this locus represents a common genetic factor in inflammatory diseases. ER -