PT - JOURNAL ARTICLE AU - ZHUOLONG WANG AU - MENGTAO LI AU - XIAOFENG ZENG AU - XINJIAN LIU TI - Hepatitis B Virus-associated Antigen Deposition in Renal Tissue from Patients with Systemic Lupus Erythematosus AID - 10.3899/jrheum.111107 DP - 2012 May 01 TA - The Journal of Rheumatology PG - 974--978 VI - 39 IP - 5 4099 - http://www.jrheum.org/content/39/5/974.short 4100 - http://www.jrheum.org/content/39/5/974.full SO - J Rheumatol2012 May 01; 39 AB - Objective. To determine the significance of hepatitis B virus (HBV)-associated antigen deposition in renal tissue from patients with systemic lupus erythematosus (SLE). Methods. The medical records of 166 inpatients with lupus nephritis and 384 controls without SLE were analyzed retrospectively. Patients with SLE were classified as positive or negative depending on whether HBV-associated antigen deposition was detected in renal biopsies. Results. HBV-associated antigen deposition was mainly detected in renal tissue from patients with SLE (50.6%), primary renal glomerular disease (20.8%), and allergic purpura (21.7%). It was not detected in renal tissue from patients with diabetic nephropathy, hypertensive nephrosclerosis, thin basement membrane nephropathy, or Alport syndrome. Hepatitis B surface antigen and core antigen were deposited in the mesangial region and vascular loops. The positive group had a significantly higher frequency of IgG, IgA, and IgM deposition than the negative group (53.6% vs 30.5%; p < 0.01). There was no significant difference in the types of lupus nephritis observed between the 2 groups. Conclusion. There was a high prevalence of HBV-associated antigen deposition in renal tissue of patients with SLE by indirect immunofluorescence, which may result mainly from the cross-reactivity with deposited immunoglobulins.