TY - JOUR T1 - Parent and Child Acceptable Symptom State in Juvenile Idiopathic Arthritis JF - The Journal of Rheumatology JO - J Rheumatol SP - 856 LP - 863 DO - 10.3899/jrheum.110745 VL - 39 IS - 4 AU - GIOVANNI FILOCAMO AU - ALESSANDRO CONSOLARO AU - BENEDETTA SCHIAPPAPIETRA AU - NICOLINO RUPERTO AU - ANGELA PISTORIO AU - NICOLETTA SOLARI AU - SILVIA PEDERZOLI AU - SARA VERAZZA AU - ALBERTO MARTINI AU - ANGELO RAVELLI Y1 - 2012/04/01 UR - http://www.jrheum.org/content/39/4/856.abstract N2 - Objective. To explore the parent and child acceptable symptom state in juvenile arthritis (JA-PASS and JA-CASS, respectively) and estimate the JA-PASS and JA-CASS cutoff values for outcome measures. Methods. Children with juvenile idiopathic arthritis (JIA) and their parents completed a multi-dimensional questionnaire that included parent-reported and child-reported outcomes and a question about whether they considered the disease state as satisfactory. Additional assessments included demographic data, physician-reported outcomes, and acute-phase reactant levels. Stepwise logistic regression was used to assess contributors to JA-PASS and JA-CASS. Cutoff values of outcome measures that defined JA-PASS and JA-CASS were determined using both 75th percentile and receiver-operating characteristic (ROC) curve methods. Testing procedures included evaluation of discriminative and construct validity of the satisfaction question and assessment of reliability of JA-PASS and JA-PASS cutoffs. Results. Of 584 parents, 385 (65.9%) considered their child in JA-PASS. Of 343 children, 236 (68.8%) considered themselves in JA-CASS. Significant contributors to being in either JA-PASS or JA-CASS were absence of active joints, better rating of overall well-being, and better physical function or health. Cutoff values yielded by 75th percentile and ROC curve methods were similar. Parent, child, and physician global ratings yielded the lowest percentage of false-positive misclassification and the best tradeoff between sensitivity and specificity. The satisfaction question showed good discriminative and construct validity and the JA-PASS and JA-PASS cutoffs were found to be stable over time. Conclusion. The acceptable symptom state is a relevant concept for children with JIA and their parents and constitutes a valid outcome measure that is potentially applicable in routine practice and clinical trials. ER -