TY - JOUR T1 - Association Between Depression and Vascular Disease in Systemic Lupus Erythematosus JF - The Journal of Rheumatology JO - J Rheumatol SP - 262 LP - 268 DO - 10.3899/jrheum.110327 VL - 39 IS - 2 AU - CAROL M. GRECO AU - TRACY LI AU - ABDUS SATTAR AU - AMY H. KAO AU - NATALYA DANCHENKO AU - DANIEL EDMUNDOWICZ AU - KIM SUTTON-TYRRELL AU - RUSSELL P. TRACY AU - LEWIS H. KULLER AU - SUSAN MANZI Y1 - 2012/02/01 UR - http://www.jrheum.org/content/39/2/262.abstract N2 - Objective. Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease with increased prevalence of cardiovascular disease (CVD) and depression. Although depression may contribute to CVD risk in population-based studies, its influence on cardiovascular morbidity in SLE has not been evaluated. We evaluated the association between depression and vascular disease in SLE. Methods. A cross-sectional study was conducted from 2002–2005 in 161 women with SLE and without CVD. The primary outcome measure was a composite vascular disease marker consisting of the presence of coronary artery calcium and/or carotid artery plaque. Results. In total, 101 women met criteria for vascular disease. In unadjusted analyses, several traditional cardiovascular risk factors, inflammatory markers, adiposity, SLE disease-related factors, and depression were associated with vascular disease. In the final multivariable model, the psychological variable depression was associated with nearly 4-fold higher odds for vascular disease (OR 3.85, 95% CI 1.37, 10.87) when adjusted for other risk factors of age, lower education level, hypertensive status, waist-hip ratio, and C-reactive protein. Conclusion. In SLE, depression is independently associated with vascular disease, along with physical factors. ER -