TY - JOUR T1 - A Nonsynonymous Functional Variant of the <em>ITGAM</em> Gene Is Not Involved in Biopsy-proven Giant Cell Arteritis JF - The Journal of Rheumatology JO - J Rheumatol SP - 2598 LP - 2601 DO - 10.3899/jrheum.110685 VL - 38 IS - 12 AU - F. DAVID CARMONA AU - AURORA SERRANO AU - LUIS RODRÍGUEZ-RODRÍGUEZ AU - SANTOS CASTAÑEDA AU - JOSÉ A. MIRANDA-FILLOY AU - INMACULADA C. MORADO AU - JAVIER NARVÁEZ AU - ROSER SOLANS AU - BERNARDO SOPEÑA AU - BEGOÑA MARÍ-ALFONSO AU - AINHOA UNZURRUNZAGA AU - NORBERTO ORTEGO-CENTENO AU - RICARDO BLANCO AU - EUGENIO DE MIGUEL AU - ANA HIDALGO-CONDE AU - JAVIER MARTÍN AU - MIGUEL A. GONZÁLEZ-GAY Y1 - 2011/12/01 UR - http://www.jrheum.org/content/38/12/2598.abstract N2 - Objective. To investigate whether a functional integrin alpha M (ITGAM) variant is involved in susceptibility to and clinical manifestations of giant cell arteritis (GCA). Methods. A Spanish cohort of 437 white patients with biopsy-proven GCA and 1388 healthy controls were genotyped using the TaqMan allele discrimination technology. Results. No association was observed between ITGAM rs1143679 and GCA (p = 0.80, OR 0.97). Similarly, subphenotype analyses did not yield significant differences between the case subgroups and the control set or between GCA patients with or without the main specific features of GCA. Conclusion. Our results suggest that the ITGAM rs1143679 variant does not play an important role in the pathophysiology of GCA. ER -