RT Journal Article
SR Electronic
T1 Effects of Smoking on Disease Activity and Radiographic Progression in Early Rheumatoid Arthritis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 2536
OP 2539
DO 10.3899/jrheum.110410
VO 38
IS 12
A1 VIRGINIA RUIZ-ESQUIDE
A1 JOSÉ A. GÓMEZ-PUERTA
A1 JUAN D. CAÑETE
A1 EDUARD GRAELL
A1 IVONNE VAZQUEZ
A1 M. GUADALUPE ERCILLA
A1 ODETTE VIÑAS
A1 ANTONIO GÓMEZ-CENTENO
A1 ISABEL HARO
A1 RAIMON SANMARTÍ
YR 2011
UL http://www.jrheum.org/content/38/12/2536.abstract
AB Objective. To analyze the effects of cigarette smoking on disease activity and radiographic damage in patients with early rheumatoid arthritis (RA). Methods. Study subjects were 156 patients with early RA (< 2 yrs). Disease activity, therapeutic response, and radiographic progression were compared in smokers and nonsmokers at 24 months. Results. At baseline, ever-smokers had earlier disease onset and a closer association with the shared epitope (SE), but not more seropositive disease. No significant differences were observed in disease activity and European League Against Rheumatism therapeutic responses between smokers and nonsmokers. Multivariate analysis showed that baseline Larsen score, the HLA-DRB*04 genotype, being female, and current smoking were associated with radiographic progression. Conclusion. In patients with early RA, smoking was associated with earlier disease onset and the SE. Smoking was an independent factor of radiographic progression.