TY - JOUR T1 - Role of rs1343151 <em>IL23R</em> and rs3790567 <em>IL12RB2</em> Polymorphisms in Biopsy-proven Giant Cell Arteritis JF - The Journal of Rheumatology JO - J Rheumatol SP - 889 LP - 892 DO - 10.3899/jrheum.101046 VL - 38 IS - 5 AU - LUIS RODRÍGUEZ-RODRÍGUEZ AU - FRANCISCO D. CARMONA AU - SANTOS CASTAÑEDA AU - JOSÉ A. MIRANDA-FILLOY AU - INMACULADA C. MORADO AU - JAVIER NARVÁEZ AU - BEATRIZ MARÍ-ALFONSO AU - CARMEN GÓMEZ-VAQUERO AU - ENCARNACIÓN AMIGO-DÍAZ AU - RAQUEL RÍOS-FERNÁNDEZ AU - RICARDO BLANCO AU - JAVIER LLORCA AU - BENJAMÍN FERNÁNDEZ-GUTIÉRREZ AU - JAVIER MARTÍN AU - MIGUEL A. GONZÁLEZ-GAY Y1 - 2011/05/01 UR - http://www.jrheum.org/content/38/5/889.abstract N2 - Objective.To assess the potential association between the rs1343151 IL23R and the rs3790567 IL12RB2 polymorphisms and giant cell arteritis (GCA). We also studied whether these polymorphisms might influence the phenotypic expression of GCA. Methods.In total, 357 Spanish patients with biopsy-proven GCA and 574 matched controls were assessed. DNA from patients and controls was obtained from peripheral blood. Samples were genotyped for the rs1343151 IL23R and the rs3790567 IL12RB2 polymorphisms using a predesigned TaqMan allele discrimination assay and by polymerase chain reaction amplification. Results.Regarding the rs1343151 IL23R polymorphism, no significant differences in the genotype or allele frequencies between GCA patients and healthy controls were observed. The frequency of the minor allele A of the rs3790567 IL12RB2 variant was increased in GCA patients compared with controls (30.1% vs 25.7%, respectively; p = 0.039, OR 1.25, 95% CI 1.01–1.54). An increased frequency of subjects carrying the minor allele A (GA+AA genotypes) of the rs3790567 IL12RB2 polymorphism was found among GCA patients compared with controls (52.8% vs 44.4%; p = 0.013, OR 1.40, 95% CI 1.06–1.85). Although a higher frequency of the combination of minor alleles (A-A) in the subgroup of patients with visual ischemic complications compared with the combination of both major alleles (G-G; p = 0.029) or with the other allelic combinations (p = 0.035) was found, logistic regression analysis showed that this association was no longer significant after adjustment for potential confounding factors (A-A vs G-G: OR 2.10, 95% CI 0.88–5.04, p = 0.096). Conclusion.Our results support a potential influence of the rs3790567 IL12RB2 polymorphism in the pathogenesis of GCA. ER -