RT Journal Article SR Electronic T1 Candidate Gene Association Study of Magnetic Resonance Imaging-based Hip Osteoarthritis (OA): Evidence for COL9A2 Gene as a Common Predisposing Factor for Hip OA and Lumbar Disc Degeneration JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 747 OP 752 DO 10.3899/jrheum.100080 VO 38 IS 4 A1 ANNU NÄKKI A1 TAPIO VIDEMAN A1 URHO M. KUJALA A1 MATTI SUHONEN A1 MINNA MÄNNIKKÖ A1 LEENA PELTONEN A1 MICHELE C. BATTIÉ A1 JAAKKO KAPRIO A1 JANNA SAARELA YR 2011 UL http://www.jrheum.org/content/38/4/747.abstract AB Objective. To study whether gene variants associated with lumbar disc degeneration (LDD) phenotypes are also associated with hip osteoarthritis (OA). Methods. Magnetic resonance imaging (MRI)-based hip OA changes for 345 twins were assessed and 99 single-nucleotide polymorphisms (SNP) were analyzed. Results. Variants in the COL9A2 (rs7533552, p = 0.0025) and COL10A1 (rs568725, p = 0.002) genes showed association with hip OA. Conclusion. The associating G allele in COL9A2 changes a glutamine to arginine or to tryptophan and may predispose to both hip OA and LDD, making it a candidate for degenerative connective tissue diseases.