TY - JOUR T1 - Candidate Gene Association Study of Magnetic Resonance Imaging-based Hip Osteoarthritis (OA): Evidence for <em>COL9A2</em> Gene as a Common Predisposing Factor for Hip OA and Lumbar Disc Degeneration JF - The Journal of Rheumatology JO - J Rheumatol SP - 747 LP - 752 DO - 10.3899/jrheum.100080 VL - 38 IS - 4 AU - ANNU NÄKKI AU - TAPIO VIDEMAN AU - URHO M. KUJALA AU - MATTI SUHONEN AU - MINNA MÄNNIKKÖ AU - LEENA PELTONEN AU - MICHELE C. BATTIÉ AU - JAAKKO KAPRIO AU - JANNA SAARELA Y1 - 2011/04/01 UR - http://www.jrheum.org/content/38/4/747.abstract N2 - Objective. To study whether gene variants associated with lumbar disc degeneration (LDD) phenotypes are also associated with hip osteoarthritis (OA). Methods. Magnetic resonance imaging (MRI)-based hip OA changes for 345 twins were assessed and 99 single-nucleotide polymorphisms (SNP) were analyzed. Results. Variants in the COL9A2 (rs7533552, p = 0.0025) and COL10A1 (rs568725, p = 0.002) genes showed association with hip OA. Conclusion. The associating G allele in COL9A2 changes a glutamine to arginine or to tryptophan and may predispose to both hip OA and LDD, making it a candidate for degenerative connective tissue diseases. ER -