%0 Journal Article %A ANNU NÄKKI %A TAPIO VIDEMAN %A URHO M. KUJALA %A MATTI SUHONEN %A MINNA MÄNNIKKÖ %A LEENA PELTONEN %A MICHELE C. BATTIÉ %A JAAKKO KAPRIO %A JANNA SAARELA %T Candidate Gene Association Study of Magnetic Resonance Imaging-based Hip Osteoarthritis (OA): Evidence for COL9A2 Gene as a Common Predisposing Factor for Hip OA and Lumbar Disc Degeneration %D 2011 %R 10.3899/jrheum.100080 %J The Journal of Rheumatology %P 747-752 %V 38 %N 4 %X Objective. To study whether gene variants associated with lumbar disc degeneration (LDD) phenotypes are also associated with hip osteoarthritis (OA). Methods. Magnetic resonance imaging (MRI)-based hip OA changes for 345 twins were assessed and 99 single-nucleotide polymorphisms (SNP) were analyzed. Results. Variants in the COL9A2 (rs7533552, p = 0.0025) and COL10A1 (rs568725, p = 0.002) genes showed association with hip OA. Conclusion. The associating G allele in COL9A2 changes a glutamine to arginine or to tryptophan and may predispose to both hip OA and LDD, making it a candidate for degenerative connective tissue diseases. %U https://www.jrheum.org/content/jrheum/38/4/747.full.pdf