RT Journal Article
SR Electronic
T1 Positive Correlation Between Beta-3-Adrenergic Receptor (<em>ADRB3</em>) Gene and Gout in a Chinese Male Population
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 738
OP 740
DO 10.3899/jrheum.101037
VO 38
IS 4
A1 BINBIN WANG
A1 DONGMEI MENG
A1 JING WANG
A1 ZHAOTONG JIA
A1 SIRUI ZHOUB
A1 SHIGUO LIU
A1 NAN CHU
A1 LIN HAN
A1 KUN ZHANG
A1 XU MA
A1 CHANGGUI LI
YR 2011
UL http://www.jrheum.org/content/38/4/738.abstract
AB Objective. The common polymorphism rs4994 [c. T387C, p. Trp64Arg (W64R)] of the lipolysis regulator beta-3-adrenergic receptor (ADRB3) was identified as a marker in the pathogenesis of hyperuricemia. As gout is characterized by elevated serum concentrations of uric acid, we investigated ADRB3 as a potential candidate for gout. Methods. This was a prospective case-control study in a group of 421 male patients with gout and 312 gout-free male controls to genotype the single-nucleotide polymorphism rs4994 of ADRB3 gene. Results. Our results showed that the C allele carrier confers a significantly higher risk for development of gout [chi-square = 4.91, df = 1, p = 0.027, OR 1.95 (adjusted by age, total cholesterol level, and body mass index), 95% CI 1.22–3.13 by dominant mode]. There was significantly higher uric acid level in carriers of the Arg64/Arg64 genotype in controls compared to non-carriers (480.5 mmol/l vs 315.0 mmol/l, respectively). Conclusion. ADRB3 rs4994 polymorphism is a potential candidate for the pathogenesis of gout in a male Chinese population.