PT  - JOURNAL ARTICLE
AU  - BINBIN WANG
AU  - DONGMEI MENG
AU  - JING WANG
AU  - ZHAOTONG JIA
AU  - SIRUI ZHOUB
AU  - SHIGUO LIU
AU  - NAN CHU
AU  - LIN HAN
AU  - KUN ZHANG
AU  - XU MA
AU  - CHANGGUI LI
TI  - Positive Correlation Between Beta-3-Adrenergic Receptor (<em>ADRB3</em>) Gene and Gout in a Chinese Male Population
AID  - 10.3899/jrheum.101037
DP  - 2011 Apr 01
TA  - The Journal of Rheumatology
PG  - 738--740
VI  - 38
IP  - 4
4099  - http://www.jrheum.org/content/38/4/738.short
4100  - http://www.jrheum.org/content/38/4/738.full
SO  - J Rheumatol2011 Apr 01; 38
AB  - Objective. The common polymorphism rs4994 [c. T387C, p. Trp64Arg (W64R)] of the lipolysis regulator beta-3-adrenergic receptor (ADRB3) was identified as a marker in the pathogenesis of hyperuricemia. As gout is characterized by elevated serum concentrations of uric acid, we investigated ADRB3 as a potential candidate for gout. Methods. This was a prospective case-control study in a group of 421 male patients with gout and 312 gout-free male controls to genotype the single-nucleotide polymorphism rs4994 of ADRB3 gene. Results. Our results showed that the C allele carrier confers a significantly higher risk for development of gout [chi-square = 4.91, df = 1, p = 0.027, OR 1.95 (adjusted by age, total cholesterol level, and body mass index), 95% CI 1.22–3.13 by dominant mode]. There was significantly higher uric acid level in carriers of the Arg64/Arg64 genotype in controls compared to non-carriers (480.5 mmol/l vs 315.0 mmol/l, respectively). Conclusion. ADRB3 rs4994 polymorphism is a potential candidate for the pathogenesis of gout in a male Chinese population.