PT  - JOURNAL ARTICLE
AU  - ANGELA E. GLIDDON
AU  - CAROLINE J. DORÉ
AU  - JULIET DUNPHY
AU  - ZOË BETTERIDGE
AU  - NEIL J. McHUGH
AU  - PETER J. MADDISON
AU  - the QUINS Trial Study Group
TI  - Antinuclear Antibodies and Clinical Associations in a British Cohort with Limited Cutaneous Systemic Sclerosis
AID  - 10.3899/jrheum.100754
DP  - 2011 Apr 01
TA  - The Journal of Rheumatology
PG  - 702--705
VI  - 38
IP  - 4
4099  - http://www.jrheum.org/content/38/4/702.short
4100  - http://www.jrheum.org/content/38/4/702.full
SO  - J Rheumatol2011 Apr 01; 38
AB  - Objective. To assess the prevalence of disease-specific autoantibodies in patients with limited cutaneous systemic sclerosis (lcSSc). Methods. Sera from 180 patients with lcSSc were analyzed for antinuclear antibody (ANA). Clinical characteristics were compared in the presence or absence of specific autoantibodies. Results. SSc-specific antibodies were detected in 135 patients (75%). Associations were found between anticentromere antibody and age at lcSSc diagnosis, telangiectasia, reduced creatinine clearance, and selective reduction in DLCO, and between antitopoisomerase-I and pulmonary fibrosis. Conclusion. The majority of patients with lcSSc belong to distinctive serologic subsets, potentially with prognostic significance.