PT  - JOURNAL ARTICLE
AU  - CHUAN WANG
AU  - HEIDI KOKKONEN
AU  - JOHANNA K. SANDLING
AU  - MARTIN JOHANSSON
AU  - MARIA SEDDIGHZADEH
AU  - LEONID PADYUKOV
AU  - SOLBRITT RANTAPÄÄ-DAHLQVIST
AU  - ANN-CHRISTINE SYVÄNEN
TI  - Preferential Association of Interferon Regulatory Factor 5 Gene Variants with Seronegative Rheumatoid Arthritis in 2 Swedish Case-Control Studies
AID  - 10.3899/jrheum.110322
DP  - 2011 Oct 01
TA  - The Journal of Rheumatology
PG  - 2130--2132
VI  - 38
IP  - 10
4099  - http://www.jrheum.org/content/38/10/2130.short
4100  - http://www.jrheum.org/content/38/10/2130.full
SO  - J Rheumatol2011 Oct 01; 38
AB  - Objective. Two interferon regulatory factor 5 (IRF5) gene variants were examined for association with rheumatoid arthritis (RA). Methods. A total of 2300 patients with RA and 1836 controls were recruited from 2 independent RA studies in Sweden. One insertion-deletion polymorphism (CGGGG indel) and one single-nucleotide polymorphism (rs10488631) in the IRF5 gene were genotyped and analyzed within RA subgroups stratified by rheumatoid factor (RF) and anticitrullinated peptide antibodies (ACPA). Results. The CGGGG indel was preferentially associated with the RF-negative (OR 1.29, p = 7.9 × 10−5) and ACPA-negative (OR 1.27, p = 7.3 × 10−5) RA subgroups compared to the seropositive counterparts. rs10488631 was exclusively associated within the seronegative RA subgroups (RF-negative: OR 1.24, p = 0.016; ACPA-negative: OR 1.27, p = 4.1 × 10−3). Conclusion. Both the CGGGG indel and rs10488631 are relevant for RA susceptibility, especially for seronegative RA.