TY - JOUR T1 - Enhancement of the Affinity of Glucocorticoid Receptors as a Mechanism Underlying the Steroid-sparing Effect of Intravenous Immunoglobulin JF - The Journal of Rheumatology JO - J Rheumatol SP - 2275 LP - 2275 DO - 10.3899/jrheum.110087 VL - 38 IS - 10 AU - ANASTAS PASHOV AU - SANDRINE DELIGNAT AU - JAGADEESH BAYRY AU - SRINI V. KAVERI Y1 - 2011/10/01 UR - http://www.jrheum.org/content/38/10/2275.abstract N2 - To the Editor:Intravenous immunoglobulin (IVIG) is commonly used for the treatment of a wide range of autoimmune diseases1,2,3. The available data also suggest that IVIG has a steroid-sparing effect: either enhancing the steroid sensitivity or reducing the steroid dose4,5,6. These reports indicate that IVIG can be considered as a therapeutic choice in steroid-resistant autoimmune and inflammatory diseases such as dermatomyositis, asthma, and polymyositis. We aimed to identify the underlying molecular mechanisms by which IVIG therapy can restore steroid sensitivity and can as a “steroid-sparing” … Address correspondence to S.V. Kaveri; E-mail: srini.kaveri{at}crc.jussieu.fr ER -