TY - JOUR T1 - Genetic Studies of Ankylosing Spondylitis in Koreans Confirm Associations with <em>ERAP1</em> and 2p15 Reported in White Patients JF - The Journal of Rheumatology JO - J Rheumatol SP - 322 LP - 324 DO - 10.3899/jrheum.100652 VL - 38 IS - 2 AU - SO-YOUNG BANG AU - TAE-HWAN KIM AU - BITNARA LEE AU - EUNJI KWON AU - SANG HYUN CHOI AU - KI SOO LEE AU - SEUNG CHEOL SHIM AU - ANGELA POPE AU - PROTON RAHMAN AU - JOHN D. REVEILLE AU - ROBERT D. INMAN Y1 - 2011/02/01 UR - http://www.jrheum.org/content/38/2/322.abstract N2 - Objective. Investigators from the Australo-Anglo-American Spondyloarthritis Consortium have reported additional genes associated with ankylosing spondylitis (AS) susceptibility including IL1R2, ANTXR2, and gene deserts at 2p15 and 21q22. We evaluated these new candidate genes in a large cohort of Korean patients with AS. Methods. A group of 1164 patients with AS and 752 healthy controls were enrolled for our study. Eight single-nucleotide polymorphisms (SNP) were analyzed to define genetic association with AS by MassARRAY system. Results. Significant positive associations of AS with endoplasmic reticulum aminopeptidase 1 SNP, rs27037 (p = 1.31 × 10−4), and rs27434 (p = 4.59 × 10−6), were observed. The rs10865331 of gene desert at 2p15 also showed a significant association with AS (p = 4.63 × 10−5). Conclusion. This is the first confirmation in a nonwhite population that genetic polymorphisms of rs27037, rs27434, and rs10865331 are associated with AS, implicating common pathogenetic mechanisms in Korean and white patients with AS. ER -