@article {BANG322, author = {SO-YOUNG BANG and TAE-HWAN KIM and BITNARA LEE and EUNJI KWON and SANG HYUN CHOI and KI SOO LEE and SEUNG CHEOL SHIM and ANGELA POPE and PROTON RAHMAN and JOHN D. REVEILLE and ROBERT D. INMAN}, title = {Genetic Studies of Ankylosing Spondylitis in Koreans Confirm Associations with ERAP1 and 2p15 Reported in White Patients}, volume = {38}, number = {2}, pages = {322--324}, year = {2011}, doi = {10.3899/jrheum.100652}, publisher = {The Journal of Rheumatology}, abstract = {Objective. Investigators from the Australo-Anglo-American Spondyloarthritis Consortium have reported additional genes associated with ankylosing spondylitis (AS) susceptibility including IL1R2, ANTXR2, and gene deserts at 2p15 and 21q22. We evaluated these new candidate genes in a large cohort of Korean patients with AS. Methods. A group of 1164 patients with AS and 752 healthy controls were enrolled for our study. Eight single-nucleotide polymorphisms (SNP) were analyzed to define genetic association with AS by MassARRAY system. Results. Significant positive associations of AS with endoplasmic reticulum aminopeptidase 1 SNP, rs27037 (p = 1.31 {\texttimes} 10-4), and rs27434 (p = 4.59 {\texttimes} 10-6), were observed. The rs10865331 of gene desert at 2p15 also showed a significant association with AS (p = 4.63 {\texttimes} 10-5). Conclusion. This is the first confirmation in a nonwhite population that genetic polymorphisms of rs27037, rs27434, and rs10865331 are associated with AS, implicating common pathogenetic mechanisms in Korean and white patients with AS.}, issn = {0315-162X}, URL = {https://www.jrheum.org/content/38/2/322}, eprint = {https://www.jrheum.org/content/38/2/322.full.pdf}, journal = {The Journal of Rheumatology} }