TY - JOUR T1 - Influence of <em>IL6R</em> rs8192284 Polymorphism Status in Disease Activity in Rheumatoid Arthritis JF - The Journal of Rheumatology JO - J Rheumatol SP - 1579 LP - 1581 DO - 10.3899/jrheum.091455 VL - 37 IS - 8 AU - JOSÉ RAMÓN LAMAS AU - LUIS RODRÍGUEZ-RODRÍGUEZ AU - JEZABEL VARADÉ AU - PEDRO LÓPEZ-ROMERO AU - PILAR TORNERO-ESTEBAN AU - LYDIA ABASOLO AU - ELENA URCELAY AU - BENJAMÍN FERNÁNDEZ-GUTIÉRREZ Y1 - 2010/08/01 UR - http://www.jrheum.org/content/37/8/1579.abstract N2 - Objective. To analyze the influence of IL6R rs8192284 polymorphism on the disease activity of rheumatoid arthritis (RA). Methods. Patients with RA (n = 281) were followed for a median of 4.2 years. A total of 1143 disease activity measurements using the 28-joint count Disease Activity Score (DAS28) were performed. A mixed-effect model was used to analyze the measurements. Results. A statistically significant interaction was observed between IL6R rs8192284 polymorphism and the presence of anticyclic citrullinated peptide (anti-CCP) antibodies (p = 0.008). An inverse relationship between the polymorphism and DAS28 was observed depending on anti-CCP status. Conclusion. The anti-CCP status in patients with RA determines the association between the IL6R rs8192284 polymorphism and disease activity. ER -