@article {MEHRANI64, author = {TARANEH MEHRANI and MICHELLE PETRI}, title = {Association of IgA Anti-{\ss}2 Glycoprotein I with Clinical and Laboratory Manifestations of Systemic Lupus Erythematosus}, volume = {38}, number = {1}, pages = {64--68}, year = {2011}, doi = {10.3899/jrheum.100568}, publisher = {The Journal of Rheumatology}, abstract = {Objective. IgA isotypes of anticardiolipin and anti-{\ss}2 glycoprotein I (anti-{\ss}2-GPI) are omitted from the revised antiphospholipid syndrome (APS) classification criteria. Multiple studies have found a high prevalence of IgA anti-{\ss}2-GPI in systemic lupus erythematosus (SLE). We determined the frequency and associations of IgA anti-{\ss}2-GPI in a cohort of patients with SLE. Methods. Anti-{\ss}2-GPI was measured in 796 patients with SLE (93\% women, 53\% white, 38\% African American, mean age 45 yrs). IgA anti-{\ss}2-GPI (\> 20 phospholipid units) was found in 20\%. Using a cohort database, associations with cumulative thrombotic and other manifestations were determined. Results. Of patients with SLE who demonstrated IgA anti-{\ss}2-GPI positivity, about 6\% had transient ischemic attack (p = 0.070), 4\% had superficial thrombophlebitis (p = 0.647), 20\% had deep venous thrombosis (p = 0.003), 4\% had other venous thrombosis (p = 0.827), 12\% had stroke (p = 0.050), and 1\% had myocardial infarction (p = 0.397). Conclusion. IgG anti-{\ss}2-GPI has the strongest association with thrombosis in SLE. However, IgA anti-{\ss}2-GPI was more strongly associated with deep venous thrombosis and with stroke than was IgM. These results indicate that assessment of IgA anti-{\ss}2-GPI is associated with thrombosis in SLE, and that the classification criteria for APS should be revised to include IgA anti-{\ss}2-GPI in patients with SLE.}, issn = {0315-162X}, URL = {https://www.jrheum.org/content/38/1/64}, eprint = {https://www.jrheum.org/content/38/1/64.full.pdf}, journal = {The Journal of Rheumatology} }