PT - JOURNAL ARTICLE AU - ROGELIO J. PALOMINO-MORALES AU - LINA-MARCELA DIAZ-GALLO AU - TORSTEN WITTE AU - JUAN-MANUEL ANAYA AU - JAVIER MARTÍN TI - Influence of STAT4 Polymorphism in Primary Sjögren’s Syndrome AID - 10.3899/jrheum.091007 DP - 2010 May 01 TA - The Journal of Rheumatology PG - 1016--1019 VI - 37 IP - 5 4099 - http://www.jrheum.org/content/37/5/1016.short 4100 - http://www.jrheum.org/content/37/5/1016.full SO - J Rheumatol2010 May 01; 37 AB - Objective. To examine the influence of STAT4 rs7574865 gene polymorphism on patients with primary Sjögren’s syndrome (SS). Methods. Two different cohorts were studied: 69 patients with primary SS and 296 controls from Colombia and 108 patients with primary SS and 227 controls from Germany. Samples were genotyped for the STAT4 rs7574865 single-nucleotide polymorphism with a predesigned TaqMan single-nucleotide polymorphism genotyping assay. We carried out a metaanalysis of our results combined with data published to date. Results. Although no significant differences were observed in the allele frequencies of STAT4 rs7574865 gene polymorphism between patients and controls in Colombians (p = 0.28, OR 1.24, 95% CI 0.82–1.87) and Germans (p = 0.08, OR 1.40, 95% CI 0.96–2.02), the metaanalysis disclosed a significant effect of the T allele on disease (p = 4.7 × 10−6, OR 1.40, 95% CI 1.21–1.62). Conclusion. These data reinforce the influence of STAT4 gene on primary SS and as a general autoimmune gene.