TY - JOUR T1 - Delayed Clinical Response in Patients with Juvenile Idiopathic Arthritis Treated with Etanercept JF - The Journal of Rheumatology JO - J Rheumatol SP - 665 LP - 667 DO - 10.3899/jrheum.090550 VL - 37 IS - 3 AU - MARIEKE H. OTTEN AU - FEMKE H.M. PRINCE AU - MARINKA TWILT AU - MARION A.J. van ROSSUM AU - WINEKE ARMBRUST AU - ESTHER P.A.H. HOPPENREIJS AU - SYLVIA KAMPHUIS AU - YVONNE KOOPMAN-KEEMINK AU - NICO M. WULFFRAAT AU - SIMONE L. GORTER AU - REBECCA ten CATE AU - LISETTE W.A. van SUIJLEKOM-SMIT Y1 - 2010/03/01 UR - http://www.jrheum.org/content/37/3/665.abstract N2 - Objective. To evaluate response in patients with juvenile idiopathic arthritis (JIA) who failed to meet response criteria after 3 months of etanercept treatment. Methods. This was a prospective ongoing multicenter observational study of all Dutch patients with JIA using etanercept. Response according to American College of Rheumatology Pediatric 30 criteria was assessed at study start and at 3 and 15 months. Results. In total we studied 179 patients of median age 5.8 years at disease onset; 70% were female. Thirty-four patients did not respond after 3 months, of which 20 continued etanercept and 11 achieved response thereafter. Conclusion. The delayed clinically relevant response in a substantial proportion of patients who initially did not respond justifies the consideration of continuing therapy to at least 6 months. ER -