PT  - JOURNAL ARTICLE
AU  - MARIEKE H. OTTEN
AU  - FEMKE H.M. PRINCE
AU  - MARINKA TWILT
AU  - MARION A.J. van ROSSUM
AU  - WINEKE ARMBRUST
AU  - ESTHER P.A.H. HOPPENREIJS
AU  - SYLVIA KAMPHUIS
AU  - YVONNE KOOPMAN-KEEMINK
AU  - NICO M. WULFFRAAT
AU  - SIMONE L. GORTER
AU  - REBECCA ten CATE
AU  - LISETTE W.A. van SUIJLEKOM-SMIT
TI  - Delayed Clinical Response in Patients with Juvenile Idiopathic Arthritis Treated with Etanercept
AID  - 10.3899/jrheum.090550
DP  - 2010 Mar 01
TA  - The Journal of Rheumatology
PG  - 665--667
VI  - 37
IP  - 3
4099  - http://www.jrheum.org/content/37/3/665.short
4100  - http://www.jrheum.org/content/37/3/665.full
SO  - J Rheumatol2010 Mar 01; 37
AB  - Objective. To evaluate response in patients with juvenile idiopathic arthritis (JIA) who failed to meet response criteria after 3 months of etanercept treatment. Methods. This was a prospective ongoing multicenter observational study of all Dutch patients with JIA using etanercept. Response according to American College of Rheumatology Pediatric 30 criteria was assessed at study start and at 3 and 15 months. Results. In total we studied 179 patients of median age 5.8 years at disease onset; 70% were female. Thirty-four patients did not respond after 3 months, of which 20 continued etanercept and 11 achieved response thereafter. Conclusion. The delayed clinically relevant response in a substantial proportion of patients who initially did not respond justifies the consideration of continuing therapy to at least 6 months.