@article {SHUAI2151, author = {BO SHUAI and LIN SHEN and YAN P. YANG and JING XIE and ZHE X. SHOU and BING WEI}, title = {Low Plasma Adiponectin as a Potential Biomarker for Osteonecrosis of the Femoral Head}, volume = {37}, number = {10}, pages = {2151--2155}, year = {2010}, doi = {10.3899/jrheum.100342}, publisher = {The Journal of Rheumatology}, abstract = {Objective. To examine whether plasma adiponectin level is correlated with osteonecrosis of the femoral head (ONFH). Methods. Blood adiponectin level in patients with nontraumatic ONFH (n = 120) was compared with a group of healthy subjects (n = 120). Patients with hip osteoarthritis (OA; n = 30) and traumatic ONFH (n = 45) were included as controls. Potential compounding factors, such as plasma low-density lipoprotein (LDL), high-density lipoprotein (HDL), apolipoprotein A1 (apo A1), apolipoprotein B (apo B), total cholesterol (TC), triglycerides (TG), and C-reactive protein (CRP) were also examined. Results. Patients with nontraumatic ONFH had significantly lower plasma levels of adiponectin than the healthy controls (7.14 {\textpm} 3.53 vs 10.93 {\textpm} 3.41 μg/ml, respectively; p \< 0.001). Adiponectin level was positively correlated with HDL (r = 0.282, p \< 0.001) and age (r = 0.145, p = 0.01), yet negatively correlated with body mass index (r = -0.70, p \< 0.001), TG (r = -0.55, p\<0.001), LDL/HDL ratio (r = -0.173, p = 0.002), and CRP (r = -0.634, p \< 0.001). No correlation was seen with LDL (r = -0.017, p = 0.762). A multiple logistic regression analysis revealed that adiponectin level is an independent predictor of the presence of nontraumatic ONFH (p \< 0.001, OR 0.676, 95\% CI 0.546 to 0.845). Conclusion. Low adiponectin level is significantly associated with the presence of nontraumatic ONFH. This biomarker may be useful in assessing the potential presence of nontraumatic ONFH.}, issn = {0315-162X}, URL = {https://www.jrheum.org/content/37/10/2151}, eprint = {https://www.jrheum.org/content/37/10/2151.full.pdf}, journal = {The Journal of Rheumatology} }