%0 Journal Article %A ESPERANZA NAREDO %A ENRIQUE BATLLE-GUALDA %A M. LUZ GARCÍA-VIVAR %A ANGEL M. GARCÍA-APARICIO %A JOSE LUIS FERNÁNDEZ-SUEIRO %A MANUEL FERNÁNDEZ-PRADA %A EMILIO GINER %A MANUEL RODRIGUEZ-GOMEZ %A MARIA FRANCISCA PINA %A JULIO A. MEDINA-LUEZAS %A FRANCISCO JAVIER TOYOS %A CRISTINA CAMPOS %A RICARDO GUTIÉRREZ-POLO %A MIGUEL ANGEL FERRER %A OLGA MARTÍNEZ %A CESAR DÍAZ-TORNE %A TERESA GONZALEZ %A SERAFÍN CAMPOS %A RUBÉN QUEIRO %A MANUEL CASTAÑO-SÁNCHEZ %A JUAN JOSÉ AZNAR %A SAGRARIO BUSTABAD %A MANUEL PAEZ-CAMINO %A ROSER TUNEU %A TERESA RUIZ %A LOURDES MATEO %A MANUEL PUJOL %A ANDRÉS PONCE %A INMACULADA ROS %A ANGEL GALLEGOS %A JUAN MORENO %A DOMINGO GUMBAU %A MANUELA SIANES %A M. JOSE POVEDA-ELICES %A MONTSERRAT ROMERO-GÓMEZ %A ENRIQUE RAYA %T Power Doppler Ultrasonography Assessment of Entheses in Spondyloarthropathies: Response to Therapy of Entheseal Abnormalities %D 2010 %R 10.3899/jrheum.100136 %J The Journal of Rheumatology %P 2110-2117 %V 37 %N 10 %X Objective. To investigate the response to therapy of entheseal abnormalities assessed with power Doppler (PD) ultrasound (US) in spondyloarthropathies (SpA). Methods. A total of 327 patients with active SpA who were starting anti-tumor necrosis factor (TNF) therapy were prospectively recruited at 35 Spanish centers. A PDUS examination of 14 peripheral entheses was performed by the same investigator in each center at baseline and at 6 months. The following elementary lesions were assessed at each enthesis (presence/absence): morphologic abnormalities (hypoechogenicity and/or thickening), entheseal calcific deposits, cortical abnormalities (bone erosion and/or proliferation), adjacent bursitis and intraenthesis and perienthesis (tendon body and/or bursa) PD signal. Response to therapy of each elementary lesion was assessed by calculating change in the cumulative presence from baseline to 6 months. Intraobserver reliability of PDUS was evaluated by blindly assessing the stored baseline images 3 months after the real-time examination. Results. Complete data were obtained on 197 patients who received anti-TNF therapy for 6 months. In 91.4% of the patients there were gray-scale or PD elementary lesions at baseline and at 6 months. Cumulative entheseal morphologic abnormalities, intraenthesis PD, perienthesis PD, and bursitis showed a significant decrease from baseline to 6 months (p < 0.05). There was high intraobserver reliability for all elementary lesions (interclass correlation coefficient > 0.90, p < 0.0005). Conclusion. Entheseal morphologic abnormalities, PD signal, and bursitis were US abnormalities that were responsive to anti-TNF therapy in SpA. PDUS can be a reproducible method for multicenter monitoring of therapeutic response in enthesitis of SpA. %U https://www.jrheum.org/content/jrheum/37/10/2110.full.pdf