RT Journal Article
SR Electronic
T1 Assessing Single Joints in Arthritis Clinical Trials
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 2092
OP 2096
DO 10.3899/jrheum.090364
VO 36
IS 9
A1 HELEN I. KEEN
A1 CLIFTON O. BINGHAM III
A1 LAURENCE A. BRADLEY
A1 PHILIP G. CONAGHAN
A1 ALISON E. HEALD
A1 GURJIT S. KAELEY
A1 WALTER P. MAKSYMOWYCH
A1 ROLAND W. MOSKOWITZ
A1 H. RALPH SCHUMACHER, Jr
A1 THASIA E. WOODWORTH
A1 PHILIP J. MEASE
YR 2009
UL http://www.jrheum.org/content/36/9/2092.abstract
AB The need to develop validated outcome measures to assess response to therapies in single joints has been recognized. In 2004, a task force was established to assess established and novel outcome measures in accordance with the OMERACT filter (truth, discrimination, and feasibility) for single joint assessment. This report describes the proceedings of the single joint assessment special interest group (SIG) at OMERACT 9, including an updated literature review of imaging of the knee joints, with a focus on the extent to which these modalities fulfill the OMERACT filter. A series of studies are reported that examine patient reported, clinical examination, and imaging outcomes in therapeutic studies in knee arthritis. A summary of discussions from the meeting are presented that raise many of the ongoing challenges in establishing appropriate domains to evaluate a range of conditions and potential therapeutic interventions. Because of emerging drug candidates and modalities targeting individual joints, the ongoing work of this SIG is providing the evidence base that can be used to establish a core domain set to incorporate as outcomes in future studies.