RT Journal Article SR Electronic T1 Association Between Interleukin 1 Gene Cluster Polymorphisms and Bilateral Distal Interphalangeal Osteoarthritis JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 1977 OP 1986 DO 10.3899/jrheum.081238 VO 36 IS 9 A1 SVETLANA SOLOVIEVA A1 OLLI-PEKKA KÄMÄRÄINEN A1 ARI HIRVONEN A1 SATU HÄMÄLÄINEN A1 MARI LAITALA A1 TAPIO VEHMAS A1 KATARIINA LUOMA A1 ANNU NÄKKI A1 HILKKA RIIHIMÄKI A1 LEENA ALA-KOKKO A1 MINNA MÄNNIKKÖ A1 PÄIVI LEINO-ARJAS YR 2009 UL http://www.jrheum.org/content/36/9/1977.abstract AB Objective. To examine the association of the interleukin 1 gene (IL1) cluster polymorphisms and their haplotypes with bilateral distal interphalangeal joint osteoarthritis (DIP OA). Methods. Radiographs of both hands of 295 dentists and 248 teachers were examined and classified for the presence of OA using reference images. Bilateral DIP OA was defined by the presence of radiographic findings of grade 2 or more in at least 1 symmetrical pair of the DIP joints. We genotyped 10 single-nucleotide polymorphisms (SNP) in the IL1R1, IL1RL2, IL1A, IL1B, and IL1RN genes using polymerase chain reaction-based methods. Haplotypes were statistically reconstructed using the PHASE program. The association between the genotypes/diplotypes and bilateral DIP OA was examined with logistic regression analysis. Results. Two IL1B SNP (rs1143634 and rs1143633) were associated with bilateral DIP OA. The carriers of the IL1B rs1143634 minor allele had an increased OA risk [odds ratio (OR) 1.6; 95% confidence interval (CI) 1.08–2.26] compared to the noncarriers. The association was stronger in the dentists. The distribution of the IL1B rs1143633 genotype fit a recessive mode of inheritance (OR 3.03, 95% CI 1.35–6.83, p = 0.006). Two IL1B-IL1RN extended haplotype alleles (211-1 and 121-1) were associated with bilateral DIP OA. An interaction between the IL1B rs1143634 and the IL1R1-IL1RL2 and IL1B-IL1RN extended haplotypes and occupation (increased risk of OA among dentists only) was observed. Conclusion. Our results provide further evidence for the role of IL1 gene cluster polymorphisms in the etiology of OA and suggest that some of these may predispose DIP joints to the effects of mechanical overload.