TY - JOUR T1 - Increased Concentrations of Prostaglandin D<sub>2</sub> During Post-Fracture Bone Remodeling JF - The Journal of Rheumatology JO - J Rheumatol SP - 644 LP - 649 DO - 10.3899/jrheum.090622 VL - 37 IS - 3 AU - MAXIME A. GALLANT AU - ESTELLE CHAMOUX AU - MARTINE BISSON AU - CATARINA WOLSEN AU - JEAN-LUC PARENT AU - SOPHIE ROUX AU - ARTUR J. de BRUM-FERNANDES Y1 - 2010/03/01 UR - http://www.jrheum.org/content/37/3/644.abstract N2 - Objective. To test the hypothesis that increased concentrations of prostaglandin D2 (PGD2) correlate with bone remodeling. Studies using isolated bone cells indicate that PGD2 may be implicated in the regulation of bone homeostasis, with a positive influence on bone anabolism. We studied patients with traumatic fractures and age- and sex-matched healthy controls as an in vivo model of increased bone remodeling. Methods. Thirty-five patients with bone fracture and matched controls were recruited. Urine and sera samples were collected. Urinary 11ß-PGF2α, a PGD2 metabolite, and PGE2 metabolites (PGEM), serum lipocalin-type PGD2 synthase (L-PGDS), bone alkaline phosphatase (bone ALP), and crosslinked C-telopeptides of type I collagen (CTX) were measured. Results. At 5–6 weeks post-fracture, 11ß-PGF2α, L-PGDS, bone ALP, and CTX were significantly increased in the fracture patients compared to controls. PGEM levels were not different between groups. Levels of 11ß-PGF2α and bone ALP were positively correlated, suggesting that PGD2 may be implicated in fracture repair. Conclusion. These results support our working hypothesis that PGD2 could be implicated in the control of bone anabolism in humans. ER -